Current Issues of Pharmacy and Medical Sciences

Curr Issues Pharm Med Sci., Vol. 31, No. 4, 186-189

Anatolii Gordiienko¹, Mykola Blazheyevskyi², Ivan Iurchenko³

¹ Department of Pharmacology and Toxicology, Kharkiv State Zooveterinary Academy, 62341, Kharkiv Region, Dergachiv District, Mala Danylivka, Ukraine 
² Department of Physical and Colloidal Chemstry, National University of Pharmacy, 61168, Kharkiv, Valentynivska 4, Ukraine
³ Department of Physcolloidal Chemistry, Zaporozhye State Medical University, 69035, Zaporizhzhia, Maiakovskyi ave 26, Ukraine

 10.1515/cipms-2018-0034

© 2018 Author(s). This is an open access article distributed under the Creative Commons Attribution-NonComercial-No Derivs licence (http://creativecommons.org/licenses/by-nc-nd/3.0/)

Abstract

For comparative purposes, a quantitative estimation of antioxidant activity of phenolic compounds of different classes was conducted by way of the polarography method, via the ADP-Fe2+ model of the induced ascorbate-dependent lipid peroxidation of rat liver microsomes within an in-vitro system. As a result, it was recognized that the antioxidant properties of phenolic compounds depend on the nature and chemical structure of several substances. In respect of such activity, leaders in the classes of investigated polyphenolic compounds are: Propyl gallate = Gallotannin (Phenolcarboxylic acids and their derivatives) > Quercetin = Myricetin (Flavonols) > Luteolin (Flavo n) = Mangiferin (Xanthones) > Kaempferol (Flavonols) = Catechin (Flavans). Thus, the assessment of the inhibition ability of the lipid peroxidation of microsomes by phenolic compounds can be used as an accessible test for the preliminary quantitative estimation of their antioxidant properties.

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Keywords

lipid peroxidation of microsomes, antioxidant activity, phenolic compounds, polarography method.