Impact of Vitamin D in the improvement of respiratory function in sickle cell disease adult patients
Curr Issues Pharm Med Sci., Vol. 36, No. 1, 48-53
Azza Sajid Jabbar1
, Abeer Jafar Mohammed1 , Nawal Khalil Ibrahim2
1 College of Pharmacy, University of Basrah, Iraq
2 College of Medicine, University of Basrah, Iraq
10.2478/cipms-2023-0010
© 2023 Author(s). This is an open access article distributed under the Creative Commons Attribution-NonComercial-No Derivs licence (http://creativecommons.org/licenses/by-nc-nd/3.0/)
Abstract
The study aimed to discover the role of vitamin D in improving the respiratory function in sickle cell disease patients. In this prospective study, 188 adults were enrolled, drawn from the out-patients unit of Thalassemia Cente The collected data were categorized into three groups: group 1 included the data of 100 healthy individuals of age range of 18-50 years as control; group 2 included the data of 88 (40 males and 48 females) sickle cell disease patients in steady state before supplementation of vitamin D; group 3 represented the data of the same 88 sickle cell disease patients as measured and recorded after 6 weeks of vitamin D supplementation. Laboratory measurements including pulmonary function tests and hematological parameters, while vitamin D levels were estimated for all groups to compare the data before and after supplementation of vitamin We found significant differences in the pulmonary function tests when comparing groups. Mean value of FEV1 revealed significant differences between group 1 and 2 (p >0.05), while vitamin D supplement created a significant difference between group 2 and 3 (p >0.05).The improvement in FEV1 did not reach to that of healthy (group 1), as referred by the significant variation between group 1 and group 3 (p>0.05). The same findings were indicative within most pulmonary function tests, and the percentages of combined cases (restrictive and obstructive) were also deceased in group 3. Conclusion: supplement of vitamin D in SCD patients could result in relative improvement in lung function.
Full Text
Keywords
vitamin D, sickle cell disease, pulmonary function tests.
References
- de Oliveira JF, Vicente NG, Santos JPP, Weffort VRS. Vitamin D in children and adolescents with sickle cell disease: an integrative review. Rev Paul Pediatr. 2015;33(3):349-54.
- Ware RE, de Montalembert M, Tshilolo L, Abboud MR. Sickle cell disease. Lancet. 2017;390(10091):311-23.
- Gardner R, Leger KJ, Annesley CE, Summers C, Rivers J, Gust J, et al. Decreased rates of severe CRS seen with Early Intervention Strategies for CD19 CAR-T Cell Toxicity Management. Blood. 2016;128(22):586-6.
- Willen SM, Gladwin MT. What is the role of screening for pulmonary hypertension in adults and children with sickle cell disease? Hematology. 2017;2017(1):431-4.
- Mohammed SH, Jabbr AS, Ibrahim NK. Impact of parasitic infection with Ascaris lumbricoides on pulmonary function tests in asthmatic and non-asthmatic children. Respir Med Case Reports. 2021;34(July):101552.
- Jabbar AS, Neamah NF, Al-Darraji AH. Comparative effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on pulmonary function in hypertensive patients. J Basic Clin Physiol Pharmacol. 2022;33(2):207-12.
- Noori IF, Jabbar AS. Impact of weight reduction surgery on static and dynamic lung volumes. Ann Med Surg. 2021;66(June):102457.
- Serjeant GR. The natural history of sickle cell disease. Cold Spring Harb Perspect Med. 2013;3(10):1-12.
- Goodman BM, Artz N, Radford B, Chen IA. Prevalence of vitamin D deficiency in adults with sickle cell disease. J Natl Med Assoc. 2010;102(4):332-5.
- Arya SC, Agarwal N. Apropos “complete resolution of sickle cell chronic pain with high-dose vitamin d therapy: A case report and review of the literature.” J Pediatr Hematol Oncol. 2012;34(4):549-51.
- Soe HHK, Abas ABL, Than NN, Ni H, Singh J, Said ARBM, et al. Vitamin D supplementation for sickle cell disease. Cochrane Database Syst Rev. 2020;2020(5).
- Abdel-Wareth L, Haq A, Turner A, Khan S, Salem A, Mustafa F, et al. Total vitamin D assay comparison of the roche diagnostics “vitamin D total” electrochemiluminescence protein binding assay with the chromsystems HPLC method in a population with both D2 and D3 forms of vitamin D. Nutrients. 2013;5(3):971-80.
- Soliman AT, Eldabbagh M, Elawwa A, Ashour R, Saleem W. The effect of vitamin D therapy on hematological indices in children with vitamin D deficiency. J Trop Pediatr. 2012;58(6):523-4.
- Medrano M, Carrillo-Cruz E, Montero I, Perez-Simon JA. Vitamin D: Effect on haematopoiesis and immune system and clinical applications. Int J Mol Sci. 2018;19(9):1-25.
- Giannini S, Lee-Sundlov MM, Rivadeneyra L, Di Buduo CA, Burns R, Lau JT, et al. β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis. Nat Commun. 2020;11(1).
- Hankinson JL, Gardner RM. Standardization of spirometry. Am Rev Respir Dis. 1988;137(2):493-5.
- Wanger J, Clausen JL, Coates A, Pedersen OF, Brusasco V, Burgos F, et al. Standardisation of the measurement of lung volumes. Eur Respir J. 2005;26(3):511-22.
- Klings ES, Wyszynski DF, Nolan VG, Steinberg MH. Abnormal pulmonary function in adults with sickle cell anemia. Am J Respir Crit Care Med. 2006;173(11):1264-9.
- Hulke SM, Thakare AE. Pulmonary function in adults with sickle cell disease. Int J Biol Med Res. 2011;2(3):723-6.
- Sugimori H, Shimizu K, Makita H, Suzuki M, Konno S. A comparative evaluation of computed tomography images for the classification of spirometric severity of the chronic obstructive pulmonary disease with deep learning. Diagnostics. 2021;11(6).
- Oko-Ose JN, Iyawe V, Egbagbe E, Ebomoyi M. Lung Function Tests in sickle-cell patients in Benin City. ISRN Pulmonol. 2012;2012:1-5.
- Unal S, Oztas Y, Eskandari G, Gumus LT, Nuriman O. The association between vitamin D and inflammation in sickle cell disease. Blood. 2014;124(21):4923.
- Santoli F, Zerah F, Vasile N, Bachir D, Galacteros F, Atlan G. Pulmonary function in sickle cell disease with or without acute chest syndrome. Eur Respir J. 1998;12(5):1124-9.
- Delclaux C, Zerah-Lancner F, Bachir D, Habibi A, Monin JL, Godeau B, et al. Factors associated with dyspnea in adult patients with sickle cell disease. Chest. 2005;128(5):3336-44.
- Machado RF, Gladwin MT. Chronic sickle cell lung disease: New insights into the diagnosis, pathogenesis and treatment of pulmonary hypertension. Br J Haematol. 2005;129(4):449-64.
- Lu RP, Clark P, Mintz PD. Hyperhemolysis sydrome: A relative contraindication for transfusion. J Hosp Med. 2008;3(1):78-80.
- Turhan A, Weiss LA, Mohandas N, Coller BS, Frenette PS. Primary role for adherent leukocytes in sickle cell vascular occlusion: A new paradigm. Proc Natl Acad Sci USA. 2002;99(5):3047-51.
- Bianga VF, Nangunia M, Oponjo FM, Itongwa JM, Mushubusha JI, Colombe MM, et al. Clinical profile of sickle cell disease in children treated at “Cliniques Universitaires de Bukavu” and “Clinique Ami des Enfants”, Bukavu, Democratic Republic of the Congo. Pan Afr Med J. 2022;41:1-10.
- Faleti OA, Akodu SO, Disu EA Njokanma OF. Pulmonary functions in children with sickle cell anaemia in steady state in Lagos, Nigeria. Ann Heal Res. 2017;3(1):18-25.
- Nagose V, Rathod S. Hematological profile of sickle cell anemia subjects in Central India: A cross sectional analysis. Ann Pathol Lab Med. 2018;5(1):A87-91.
- Kato GJ, Gladwin MT, Steinberg MH. Deconstructing sickle cell disease: Reappraisal of the role of hemolysis in the development of clinical subphenotypes. Blood Rev. 2007;21(1):37-47.
- Yetgin S, Yalçin SS. The effect of vitamin D3 on CD34 progenitor cells in vitamin D deficiency rickets. Turk J Pediatr. 2004;46(2):164-6.
- Tayo BO, Akingbola TS, Salako BL, McKenzie CA, Reid M, Layden J, et al. Vitamin D levels are low in adult patients with sickle cell disease in Jamaica and West Africa. BMC Hematol. 2014;14(1):12.
- Melchionda F, Oncology P, Spreafico F, Unit PO, Hemato-oncology P, Ciceri S, et al. LETTER TO THE EDITOR A Novel WT1 Mutation in Familial Wilms Tumor. Pediatr Blood Cancer. 2013;(February):1388-9.
- Li X, He J, Yu M, Sun J. The efficacy of vitamin D therapy for patients with COPD: A meta-analysis of randomized controlled trials. Ann Cardiothorac Surg. 2020;9(2):286-97.
- Chennamasetti K, Muley A. A study of Vitamin D deficiency in patients of sickle cell disease and its association with severity. Int J Adv Med. 2020;7(4):621.
- Ganji V, Al-Obahi A, Yusuf S, Dookhy Z, Shi Z. Serum vitamin D is associated with improved lung function markers but not with prevalence of asthma, emphysema, and chronic bronchitis. Sci Rep. 2020;10(1):1-9.
- Finklea JD, Grossmann RE, Tangpricha V. Vitamin D and chronic lung disease: A review of molecular mechanisms and clinical studies. Adv Nutr. 2011;2(3):244-53.
- Nolasco R, Moreira LDF, Bocalini DS, Fronza FCAO, Marin RV, Lazaretti-Castro M. Effects of vitamin D supplementation on pulmonary function in postmenopausal women following an aquatic exercise program. Arch Endocrinol Metab. 2017;61(1):28-35.
