Current Issues of Pharmacy and Medical Sciences

Curr Issues Pharm Med Sci., Vol. 33, No. 2, 57-60

Olesya Pavlivna Balitska , Tamara Andreevna Germanyuk , Yuliia Mykolaivna Hrygoruk ,
Tatiana Ivanovna Ivko , Yuliia Oleksandrivna Tomashevska,
Vasyl Mykolayovich Koval , Yuliia Mykolayina Polishchuk ,
Viktoriia Volodymyrivna Hutsol , Myhailo Andriyovich Artemchuk

Department of Pharmacy, National Pirogov Memorial Medical University, Vinnytsya, Ukraine

 10.2478/cipms-2020-0011

© 2020 Author(s). This is an open access article distributed under the Creative Commons Attribution-NonComercial-No Derivs licence (http://creativecommons.org/licenses/by-nc-nd/3.0/)

Abstract

Aim. The aim of this study is to evaluate the efficiency of proton pump inhibitors in the treatment of gastric and duodenal ulcers as based on literature.
Materials and methods. The materials of this research are the results of 86 original studies on the effectiveness of proton pump inhibitors analysis.
Methods. Descriptive, statistical, retrospective.
Results and Conclusion. According to the clinical random researches, Omeprazole preparations are not included in the list due to proven better effectiveness of Esomeprazole drugs. Moreover, lansoprazole drugs are not included according to proven short-acid inhibitory effect. In addition, the brand of mentioned above preparation does not exist on the pharmaceutical market of Ukraine. Furthermore, rabeprazole preparations are presented in the research by Pariet (brand) and by the effective generic Barol, while pantoprazole preparations are represented in the research by Kontrolok (brand) and by the generic Pultset, as well as by Nolpaza. Herein, the Pantosan effect was not significantly different from the effect of Pultset and Nolpaza, but the preparation is much more expensive. In terms of efficiency (%), 4 week repair of mucosal defects was carried out by way of the following treatment regimens: Barol + Amoxicillin + Clarythromycin (90.9±6.2), Pariet + Amoxicillin + Clarythromycin (83±2.6), Kontrolok + Amoxicillin + Clarythromycin (100±1.3), Pultset + Amoxicillin + Clarythromycin (88±4.1), Nolpaza + Amoxicillin + Clarythromycin (72±4.1), Ezolonh + Amoxicillin + Clarythromycin (87.7±3.8), Neksium + Amoxicillin + Clarythromycin (96.1±3.1).

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Keywords

antidepressant, peptic ulcer, proton pump inhibitors, efficiency.